Retinoic Acid Therapy Attenuates the Severity of Tuberculosis While Altering Lymphocyte and Macrophage Numbers and Cytokine Expression in Rats Infected with Mycobacterium tuberculosis
Abstract
Because retinoic acid (RA) exerts a
stimulatory effect on macrophages and tubercle bacilli target alveolar
macrophages, the
therapeutic potential of RA was examined in rats
with tuberculosis. In the main study, 15 rats were randomized to
treatment
with oil (control) or RA,100 μg/100 g body weight per dose, given 3 times weekly for 3 and 5 wk after infection with Mycobacterium tuberculosis strain H37Rv.
There was a significant difference in the severity of tuberculosis
histopathology between control and RA-treated rats, and
oral administration of RA decreased the number of
colony-forming units (CFU) in both lung and spleen at 3 and 5 wk after
H37Rv
infection (P < 0.005). CD4-positive and CD8-positive T cells, natural killer cells, and CD163-positive macrophages increased (P < 0.05) in the infected lung tissues of RA-treated rats. Expression of IFNγ and inducible nitric oxide synthetase messenger RNA (mRNA) was higher in the infected lung tissues of RA-treated rats than
in control rats.
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